20 Best Acetaminophen And Guaifenesin And Phenylephrine [2024]

Are you looking for the best Acetaminophen And Guaifenesin And Phenylephrine? Based on expert reviews, we ranked them. We've listed our top-ranked picks, including the top-selling Acetaminophen And Guaifenesin And Phenylephrine.

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1 Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
2 Mucinex Sinus-Max Pressure, Pain & Cough Max Strength-Sinus Pressure, Congestion & Headache Relief,... Mucinex Sinus-Max Pressure, Pain & Cough Max Strength-Sinus Pressure, Congestion & Headache...
3 Tylenol Sinus Severe Daytime Caplets with Acetaminophen 325mg, Guaifenesin 200mg & Phenylephrine HCl... Tylenol Sinus Severe Daytime Caplets with Acetaminophen 325mg, Guaifenesin 200mg & Phenylephrine...
4 Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
5 Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
6 Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count
7 Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
8 Amazon Basic Care Daytime Cold & Flu Liquid Caps; Cold Care for Daytime Cold and Flu, 48 Count Amazon Basic Care Daytime Cold & Flu Liquid Caps; Cold Care for Daytime Cold and Flu, 48 Count
9 Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 mg - 24 Caplets |... Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 mg - 24 Caplets |...
10 GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl 10 mg, Sinus Congestion Relief;... GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl 10 mg, Sinus Congestion...
11 Rite Aid Severe Flu and Cold Relief Caplets - 24 Count | Pain Relief | Congestion Relief | Fever... Rite Aid Severe Flu and Cold Relief Caplets - 24 Count | Pain Relief | Congestion Relief | Fever...
12 TUKOL Children's Cough & Cold, 4 Fl Oz,GEN00539 TUKOL Children's Cough & Cold, 4 Fl Oz,GEN00539
13 Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 Count Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 Count
14 GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
15 HealthA2Z Mucus Relief DM, 200 Count,Dextromethorphan HBr 20mg Guaifenesin 400mg,Generic Mucinex DM... HealthA2Z Mucus Relief DM, 200 Count,Dextromethorphan HBr 20mg Guaifenesin 400mg,Generic Mucinex...
16 Amazon Basic Care Guaifenesin Extended-Release Bi-Layer Tablets, 600 mg, 12 Hour Expectorant, White,... Amazon Basic Care Guaifenesin Extended-Release Bi-Layer Tablets, 600 mg, 12 Hour Expectorant,...
17 Amazon Basic Care Daytime Cold & Flu Liquid; Cold Care for Daytime Cold and Flu, 8 Fluid Ounces Amazon Basic Care Daytime Cold & Flu Liquid; Cold Care for Daytime Cold and Flu, 8 Fluid Ounces
18 Primary Health Mucus Relief DM Maximum Strength Dextromethorphan 60mg, Guaifenesin 1200mg,... Primary Health Mucus Relief DM Maximum Strength Dextromethorphan 60mg, Guaifenesin 1200mg,...
19 HealthA2Z Mucus Relief, Guaifenesin 400mg, 300 Tablets, Immediate Release, Expectorant HealthA2Z Mucus Relief, Guaifenesin 400mg, 300 Tablets, Immediate Release, Expectorant
20 Mucinex DM 12 hour Cough and Chest Congestion Medicine -Expectorant and Cough Suppressant... Mucinex DM 12 hour Cough and Chest Congestion Medicine -Expectorant and Cough Suppressant...
Bestseller No. 1
Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
  • 24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies
  • Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure
  • Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever; 5 mg of nasal decongestant phenylephrine HCl to help clear...
  • The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and...
  • From the #1 doctor-recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older
Bestseller No. 2
Mucinex Sinus-Max Pressure, Pain & Cough Max Strength-Sinus Pressure, Congestion & Headache Relief,...
  • [MUCINEX SINUS-MAX PRESSURE, PAIN & COUGH CAPLETS] Maximum strength, multi-symptom relief
  • [THINS & LOOSENS MUCUS] Contains Guaifenesin, a scientifically-proven expectorant
  • [CLEARS SINUS & NASAL CONGESTION] Formula contains Phenylephrine nasal-decongestant
  • [RELIEVES HEADACHE & FEVER] Specially formulated with Acetaminophen to relieve pain and reduce fever
  • [MULTI-SYMPTOM RELIEF] Treats chest & nasal congestion, sinus pressure & congestion, fever, headache, cough, congestion & mucus
SaleBestseller No. 3
Tylenol Sinus Severe Daytime Caplets with Acetaminophen 325mg, Guaifenesin 200mg & Phenylephrine HCl...
  • Pain Reliever, Decongestant And Expectorant To Temporarily Relieve Symptoms Of Chest Congestion, Nasal Congestion, Sinus Headache And Pressure.
  • The Non-Drowsy Formula Of This Sinus Medicine Provides Effective Daytime Symptom Relief By Promoting Sinus Drainage.
  • Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy cold, flu & allergy symptom relief
  • Pain reliever, decongestant, fever reducer & expectorant to help relieve sinus headache & pressure
  • Cold & flu symptom relief medicine helps decongest sinus openings & passages & loosens phlegm
Bestseller No. 4
Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
  • 24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies
  • Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure
  • Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever; 5 mg of nasal decongestant phenylephrine HCl to help clear...
  • The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and...
  • From the #1 doctor-recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older
Bestseller No. 5
Tylenol Sinus Severe Daytime Caplets with Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct
  • 24-count of Tylenol Sinus Severe Daytime Caplets for non-drowsy symptom relief due to the common cold, hay fever or other respiratory allergies
  • Pain reliever, decongestant and expectorant to temporarily relieve symptoms of chest congestion, nasal congestion, sinus headache and pressure
  • Each caplet contains 325 mg of acetaminophen to temporarily relieve pain and reduce fever; 5 mg of nasal decongestant phenylephrine HCl to help clear...
  • The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and...
  • From the #1 doctor-recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older
Bestseller No. 6
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count
  • ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient...
  • Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold,...
  • USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
  • PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
  • ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
SaleBestseller No. 7
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
  • ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active...
  • PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary...
  • TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual...
  • ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer,...
  • PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a...
Bestseller No. 8
Amazon Basic Care Daytime Cold & Flu Liquid Caps; Cold Care for Daytime Cold and Flu, 48 Count
  • ACTIVE INGREDIENTS: This cold medicine contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant) and...
  • MULTI-SYMPTOM RELIEF: This cold remedy temporarily relieves headache, fever, sore throat, minor aches and pains, nasal congestion and cough due to the...
  • PAIN RELIEVER AND FEVER REDUCER: Cold relief medicine temporarily relieves minor aches and pains, headache, fever and sore throat due to the common...
  • COUGH SUPPRESSANT: Choose the right cold remedy for your cough during cold and flu season. This product acts as a cough suppressant to temporarily...
  • NASAL DECONGESTANT: Cold and flu season often brings nasal congestion as a symptom. This cold relief medicine will help temporarily relieve this...
Bestseller No. 9
Rite Aid Daytime Severe Sinus Congestion & Pain Relief - Acetaminophen, 325 mg - 24 Caplets |...
  • FEVER & PAIN RELIEVER: 325mg of Acetaminophen in each caplet temporally relieves common cold symptoms like minor aches and pains, headache, sore...
  • MULTI-SYMPTOM RELIEF: Rite Aid Severe Sinus Congestion & Pain Relief relieves headache, nasal congestion, sinus congestion and sinus pressure, chest...
  • DAYTIME NON-DROWSY FORMULA: With Rite Aid cold medicine for adults, you’ll feel relief from symptoms associated with the common cold— formulated...
  • FOR YOUR SEVERE SYMPTOMS: With Rite Aid Severe Cold & Flu sinus medicine for adults, you’ll get a pain reliever/fever reducer, cough suppressant to...
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the...
Bestseller No. 10
GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl 10 mg, Sinus Congestion Relief;...
  • ACTIVE INGREDIENT: The active ingredient in GoodSense Maximum Strength Nasal Decongestant PE is phenylephrine HCl 10 mg, a nasal decongestant, which...
  • NASAL DECONGESTANT: This product provides maximum strength, non-drowsy relief for nasal and sinus congestion, and sinus pressure due to the common...
  • MAXIMUM STRENGTH: GoodSense Maximum Strength Nasal Decongestant PE provides maximum strength relief for sinus pressure, nasal and sinus congestion
  • NON-DROWSY relief so you can power through your day
  • ASPIRIN AND GLUTEN FREE. GoodSense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl, 10 mg does not contain pseudoephedrine
Bestseller No. 11
Rite Aid Severe Flu and Cold Relief Caplets - 24 Count | Pain Relief | Congestion Relief | Fever...
  • MULTI-SYMPTOM RELIEF: You’ll feel relief from headache, fever, sore throat, nasal congestion, cough, mucus, and chest congestion with Rite Aid....
  • FOR YOUR SEVERE SYMPTOMS: With Rite Aid Severe Cold & Flu sinus medicine for adults, you’ll get a pain reliever/fever reducer, cough suppressant to...
  • FEVER & PAIN RELIEVER: 325mg of Acetaminophen in each caplet temporarily relieves common cold symptoms like minor aches and pains, headache, sore...
  • COOL BLAST: You’ll know it’s working when you feel the cool blast flavor. Rite Aid’s Severe Cold & Flu has Acetaminophen 325mg; cough...
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the...
SaleBestseller No. 12
TUKOL Children's Cough & Cold, 4 Fl Oz,GEN00539
  • Cough and Cold Syrup for Kids: This non-drowsy medication provides powerful cold symptom relief, working as an expectorant and decongestant to relieve...
  • Children's Formula: Specially formulated for children 4 and over, this non-drowsy syrup starts working fast to bring your child relief, featuring a...
  • Multi-Symptom Treatment: Whether you're dealing with congestion, cold, flu, sore throat or a persistent cough, we've got the remedy for you, available...
  • Tukol Relief: We make an array of products for the relief of cough, cold, sore throat, fever and flu, for children and adults; Try our liquid cough...
SaleBestseller No. 13
Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 Count
  • 24-count box of Sudafed PE Head Congestion + Mucus Tablets to provide non-drowsy relief from sinus pain and pressure, nasal & chest congestion, and...
  • Sinus relief medicine contains 5 mg of phenylephrine HCl, a decongestant, for congestion relief and 325 mg of acetaminophen for pain and fever...
  • Head congestion tablets temporary relieves symptoms associated with hay fever, upper respiratory allergies, and the common cold
  • Non-drowsy decongestant tablets provide relief of sinus pressure, headaches, nasal and chest congestion, excess mucus, and minor aches and pains
  • Head congestion relief medicine also helps loosen mucus to clear bronchial passageways and make coughs more productive Get powerful head congestion...
Bestseller No. 14
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
  • ACTIVE INGREDIENT: GoodSense Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra...
  • GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache,...
  • USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
  • PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
  • ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
Bestseller No. 15
HealthA2Z Mucus Relief DM, 200 Count,Dextromethorphan HBr 20mg Guaifenesin 400mg,Generic Mucinex DM...
  • Made In USA / Contains Guaifenesin which helps loosen and thin mucus, making it easier to expectorate.
  • The active ingredient dextromethorphan works as a suppressant which helps reduce the frequency and intensity of your cough.
  • Coughs become more productive and sleep improves
  • Adults and children 12 years and older: Take 1 tablet every 4 hours with a full glass of water while symptoms exit. Do not to exceed 6 doses in 24...
Bestseller No. 16
Amazon Basic Care Guaifenesin Extended-Release Bi-Layer Tablets, 600 mg, 12 Hour Expectorant, White,...
  • ACTIVE INGREDIENT: Amazon Basic Care Cough and Mucus Relief contains Guaifenesin 600 mg, an expectorant; compare to the active ingredient in Mucinex
  • 12-HOUR RELIEF: Get immediate and long-lasting chest congestion relief; just one dose releases the regular strength phlegm relief medicine you need...
  • COUGH EXPECTORANT: Trust Guaifenesin 600 mg to thin and loosen mucus to make coughs more productive
  • MUCUS RELIEF: Amazon Basic Care Cough and Mucus Relief Extended-Release Tablets relieve chest congestion caused by excess phlegm
  • GLUTEN FREE: This product is free of gluten; safe for adults and children 12 years of age and older
Bestseller No. 17
Amazon Basic Care Daytime Cold & Flu Liquid; Cold Care for Daytime Cold and Flu, 8 Fluid Ounces
  • ACTIVE INGREDIENTS: This cold and flu medicine contains acetaminophen (pain reliever/fever reducer), dextromethorphan HBr (cough suppressant) and...
  • MULTI-SYMPTOM RELIEF: Temporarily relieves headache, fever, sore throat, minor aches and pains, nasal congestion and cough due to the common cold and...
  • NON-DROWSY: Each dose is designed for daytime use, so you can get through the day
  • MAXIMUM STRENGTH: When a cold or flu strikes, you need powerful relief
  • FOR AGES 6 AND OVER: For adults and children ages 6 and older; take as directed for cold and flu medicine that is alcohol, antihistamine and gluten...
Bestseller No. 18
Primary Health Mucus Relief DM Maximum Strength Dextromethorphan 60mg, Guaifenesin 1200mg,...
  • Compare to maximum strength Mucinex DM active ingredients
  • Expectorant helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more...
  • Temporarily relieves cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants, the intensity of...
  • 12-Hour extended-release cough suppressant and Expectorant tablets
  • For ages 12 and older
SaleBestseller No. 19
HealthA2Z Mucus Relief, Guaifenesin 400mg, 300 Tablets, Immediate Release, Expectorant
  • Made In USA / The active ingredient Guaifenesin helps loosen and thin mucus, making it easier to expectorate.
  • It contains a powerful aid in reducing the frequency and intensity of your cough.
  • Coughs become more productive and sleep is improved.
  • Adults and children 12 years and older: Take 1 tablet every 4 hours with a full glass of water while symptoms exit. Do not to exceed 6 doses in 24...
SaleBestseller No. 20
Mucinex DM 12 hour Cough and Chest Congestion Medicine -Expectorant and Cough Suppressant...
  • Controls cough and thins and loosens mucus to make coughs more productive and help relieve chest congestion.
  • Immediate and Extended Relief that lasts up to 12 hours. Mucinex pantented bi-layer tablet contains an immediate-release layer on one side and...
  • Dosage: Adults and children 12 years of age and over: 1 or 2 tablets every 12 hours. Do not exceed 4 tablets in 24 hours. Children under 12 years of...
  • Active Ingredients: Guaifenesin 600 mg (expectorant) & Dextromethorphan HBr 30 mg (cough suppressant) (In each extended-release bi-layer tablet)
  • Mucinex is the no.1 doctor recommended OTC expectorant among Internists, General Practitioners and Family Practitioners

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FAQ:

Q: Can you mix acetaminophen and phenylephrine?

A: When phenylephrine is combined with acetaminophen, blood levels of phenylephrine rise to four times higher than when the same amount of phenylephrine is used alone, Atkinson said. “Basically, if you give the combination, a lot more phenylephrine absorbs into your body than what you would be expecting,” Atkinson said.

Q: Is there hydrocodone with acetaminophen?

A: Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time.

Q: Does azithromycin contain acetaminophen?

A: It may contain a cough suppressant ( dextromethorphan ), antihistamine ( chlorpheniramine ), mucolytic (guaifenesin), analgesic/fever med ( acetaminophen ). There is no known interactions with any of these agents with azithromycin.

Q: Is phenylephrine as good as pseudoephedrine?

A: Yes. Most patients and healthcare providers will agree that Sudafed (pseudoephedrine) is more effective for congestion than its counterpart Sudafed PE (phenylephrine). This is likely due to the fact that the intestines will absorb only about 38% of the amount of Sudafed PE in one tablet, while Sudafed is 100% absorbed.